Hassan Tariq, Amna Iqbal, Hafeez-ud Din, Syed Raza Jaffar, Sardar Waleed Babar, Asma Gul.
Expression of CD56, CK19 and HBME-1 in follicular variant of papillary thyroid carcinoma and benign mimickers.
Pak J Pathol Jan ;32(1):1-4.

Objective: To assess the diagnostic utility of a set of 3 markers i.e. CD56, CK-19 and HBME-1 to differentiate follicular variant of papillary carcinoma (FVPC) from its benign mimickers. Material and Methods: This is a prospective cross-sectional study conducted at Histopathology department of Armed force institute of pathology (AFIP) Rawalpindi, Pakistan from May 2020 to Aug 2020. A cross-sectional study in which samples of 40 thyroid lesions that included 20 FVPTC and 20 hyperplasia/adenomas were retrieved from the database of the Department of Histopathology of Armed Forces Institute of Pathology, Rawalpindi. Immunohistochemistry was done to assess the expression of CD56, CK19 and HBME-1 in FVPTC (n=20) and hyperplasia/adenoma (n=20). Results were analyzed using SPSS 21. Results: Strongly positive (2+) staining with CK19 and HBME-1 was observed in 95% and 80% of the FVPTC patients respectively. Expression of CD56 was negative in 80% of FVPTC. A significant statistical difference was observed in the expression of HBME-1, CK19 and CD56 in FVPTC and benign lesions (P<0.05). Conclusion: Negative staining for CD56 in a thyroid lesion while at the same time co-expression of diffuse and strong staining with CK19 and HBME-1 in a follicular pattern lesion posing a diagnostic challenge is highly suggestive of FVPTC provided it is interpreted in the right context.

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