Tayyeba Anbreen, Lubna Ali, Sofia Butt, Tahira Shah.
Congenital anomaly frequency, risk factor and trends among antenatal patients presenting at tertiary care hospital in Pakistan.
Pak J Med Res Jan ;60(2):52-6.

Background: Congenital anomaly is known for its multifactorial origin and trends among people across the world. Karachi is a hub of people belongs to different ethnic groups from all over Pakistan. Objective: The study was conducted to determine the frequency of congenital anomalies among antenatal patients. Study type, settings & duration: This descriptive cross sectional study was conducted in the outpatient Gynae department of Civil Hospital, Karachi from January 2017 to December 2018. Methodology: The antenatal patients both booked and un-booked, diagnosed antenatal with congenitally abnormal fetus or delivered congenitally abnormal neonate were included in the study. Results: During this tenure, a total of 8908 pregnant ladies were admitted in labor room and among those 198 were diagnosed with congenitally malformed babies. The most commonly identified abnormality was of central nervous system 60.1%, followed by renal 11.61%, gastrointestinal 4.54% and others 17.6%. Various risk factors like parental age, history of previous congenital anomaly and consanguinity showed association with these anomalies. Conclusion: Early detection of these anomalies and identification of the associated risk factor will help in reducing morbidity and mortality and creating awareness to solve the issue. Key words: Congenital anomalies, neural tube defects, risk factors.

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