Ayesha Khan, Nasim Karim, Jahan Ara Ainuddin.
Impact of Pioglitazone on Anthropometric and Metabolic Parameters in PCOS Infertile Women.
J Islamic Int Med Coll Jan ;16(2):101-5.

Objective: To evaluate the effect of pioglitazone on anthropometric and metabolic parameters in infertile women suffering from polycystic ovarian syndrome (PCOS). Study Design: Randomized controlled trial. Place and Duration of Study: The study was conducted in the Pharmacology Department of Bahira University th Medical and Dental College in collaboration with infertility clinic, Mamji Hospital Karachi from 24 September th 2018 to 30 March 2019. Materials and Methods: Forty infertile women aged 20-40 years using non-probability convenient sampling technique were enrolled as per Rotterdam criteria 2003. They had fasting insulin level > 9μU/mL, the fasting glucose level of 7 mmol/L or ≥126 mg/dl, and cyclical irregularity such as oligomenorrhoea/amenorrhea. They were given tablet pioglitazone 30 mg once daily per orally for three months. All participants were subjected to evaluation of anthropometric (weight, BMI, waist and hip circumference, and waist-hip ratio) and metabolic parameters (1. carbohydrate – fasting serum glucose and insulin, 2. lipids – Total cholesterol, triglycerides, low density lipoprotein cholesterol (LDL-C), very-low-density lipoprotein cholesterol (VLDL-C), High-density lipoprotein cholesterol (HDL-C), and 3. protein–serum hs-CRP). The Paired T-test was applied for comparison at the end of three months. Data analysis was performed by SPSS version 23. Results: Thirty-one participants completed the study. We found a mean reduction of 3.17 kg in weight, BMI 1.2 2kg/m , and W/H ratio 0.018 in anthropometric parameters. Mean reduction of fasting serum glucose 19 mg/dl, insulin 6.61 µIU/ml, HDL- C 3 mg/dl, LDL-C 7 mg/dl, VLDL- C 6 mg/dl, Total cholesterol 14 mg/dl, Triglycerides 32 mg/dl and serum hs-CRP level 1.85 mg/L was found. Conclusion: Pioglitazone reduces anthropometric parameters and causes a significant reduction in metabolic parameters among polycystic ovarian syndrome infertile women

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