Muhammad Zaman, Muhammad Hanif, Muhammad Wahab Amjad, Asif Mahmood, Shahid Shah, Maria Abdul Ghafoor Raja, Shahid Rasool, Rai Muhammad Sarfraz.
Development of thiomer based buccal films for the enhancement of bioavailability: an in-vivo analysis..
Pak J Pharm Sci Jan ;32(2):759-64.

Present work was conducted to improve the bioavailability of Tizanidine HCl (TZN) by formulating mucoadhesive buccal films (MBFs) using novel thiolated arabinoxylan (TAX) as film former. MBF's were prepared by solvent casting technique followed by their evaluation for surface morphology and folding endurance. Moreover, pharmacokinetic parameters including C, t, t and AUC were determined after administering standard oral solution (SOS) and MBFs of TZN at a dose of 1mg/kg. Successful thiolation was confirmed by the presence of 4.98 to 7.04 mmol of thiol content per gram of the polymer. Results of in-vivo pharmacokinetics have signified (p=0.0089) the suitability of MBFs as a carrier of drug through buccal route. Results have explored that, t1/2 was increased from 2.51hrs (SOS) to 10 hrs, C from 42.3 ng/ml (SOS) to 105ng/ml and t from 2hrs (SOS) to 6h. Conclusively, TAX has exhibited the potential to form MBFs thereby offering sustained release of TZN with improved pharmacokinetic profile.

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