Tahira S Khokhar, Shahabuddin Memon, Qadeer K Panhwar, Fakhar N Memon, Ayaz A Memon, Muhammad Qasim Samejo, Saba Muneer, Metin Tulu.
Complexation of ibuprofen with water soluble p-sulfonatocalix [4]arene: a potential candidate for drug delivery application.
Pak J Pharm Sci Jan ;30(3):783-8.

Complexation of ibuprofen with water soluble p-sulfonatocalix[4]arene (3) was evaluated. Both molecules exhibit a host and guest type complexation. pH, complex stoichiometry and binding constant were determined by UV-Vis and FT-IR spectroscopy. The maximum complexation of 3 with ibuprofen occurs at pH 2. Stability constant values (9.897) show that there is favorable complex formed due to vital role of p-sulfonatocalix[4]arene, while the thermodynamic parameters, i.e. ?G, ?H and ?S have been found as -24.09 KJ/mol, 0.012 KJ/mol and 0.12 KJ/mol. K, respectively. The results show that 3 has efficiency to carry the drug at particular conditions and can be used for drug delivery as a carrier.

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