Haider G, Chaudhry M A, Shah M A, Munir S M, Masroor Ahmed.
Quinine compared to Artemether in adults with Cerebral Malaria.
J Surg Pak Jan ;7(1):34-5.

Quinine is the standard drug used for the treatment of cerebral malaria. Artemether is a new product and claimed to be more effective in cerebral malaria. This study was conducted to compare artemether with quinine in the treatment of cerebral malaria in Medical Unit-111, Jinnah Postgraduate Medical Centre, Karachi. Forty-one cases of proven cerebral malaria were entered in the study and randomly grouped into two groups: A (n=21) and B (n=20). Group-A was given quinine infusion and B was treated with artemether each for 7 days. In group-A, 19 patients recovered and two patients expired, while in group-B only one patient expired. Hypoglycaemia was documented in three patients in group-A and none in group-B, no other significant side effect was documented in both groups. It is concluded that both quinine and artemether are effective in the treatment of cerebral malaria. Chance of side effects is comparably greater with quinine, overall effectiveness being similar.

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