Umair Ijaz Malik, Tariq Bashir Tareen, Uzair Ijaz Malik, Hina Naseer, Mehar Rehman.
To determine the effect of gender, advanced age, longer duration of illness and higher glycosylated hemoglobin levels on mean platelet volume (MPV) in patients of type 2 diabetes mellitus.
Pak Armed Forces Med J Jan ;71(1):167-71.

Objective: To determine the effect of gender, advanced age, longer duration of illness and higher glycosylated hemoglobin levels on mean platelet volume in patients of type 2 diabetes mellitus. Study Design: Descriptive cross-sectional study. Place and Duration of Study: Combined Military Hospital Kohat, from Jul2017 to Aug2018. Methodology: In this study 248 patients with type 2 diabetes were evaluated as per inclusion/exclusion criteria. Data from all patients was collected which included age, gender, duration of disease, symptoms &signs of target organ damage, Fasting Blood Glucose at presentation, HbA1c levels and complete blood count including mean Platelet Volume. Patients were then divided into different categories according to their gender, age, duration of illness and HbA1c levels. Mean mean platelet volume for each category was calculated and compared using student t-test. Data was analyzed using SPSS-21 and means for each group were compared. Results: Sample size (n) was 248,140(57%) patients were male and 108(43%) were female with mean mean platelet volume of 11.51±0.80fLand 11.66±0.78fLrespectively. Age wise stratification showed 45patients (17%) below 50 years of age, 85patients (37%) between 50 and 59 years, 80patients(32%) between 60 and 69 years and 38patients (14%) aged 70years and more. Mean mean platelet volume for these age groups was 10.76±0.61fL, 11.36±0.68fL, 12.03±0.60fLand 12.07±0.58fLrespectively.Ninetypatients (36%) had the disease for less than 3 years, 65 patients (26%) had diabetes mellitus for 3-5 years and 93 patients (38%) had diabetes mellitus for over 5 years. Mean mean platelet volume for these patients was 11.16±0.79 fL, 11.35±0.66 fL and 12.14±0.52 fL respectively. About 111 patients (45%)had HbA1c below 7.5% and 137 patients (55%) had HbA1c above 7.5%.Mean mean platelet volume for patients with controlled diabetes mellitus (HbA1c<7.5%) was11.13±0.69fLand for those with uncontrolled diabetes mellitus was11.93±0.69 fL respectively. Means of different groups was compared using student t-test and p-value was found to be less than 0.001.Conclusion:Highermean platelet volume values are associated with a higher age, longer duration of illness and uncontrolled diseaseor poor glycemic control as shown by higher HbA1c levels in patients of type 2 diabetes mellitus. There was no significant change in mean platelet volume values with respect to gender.

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