Bari A U, Simeen Ber Rahman.
Keratoacanthoma: An uncommon benign skin tumour in Pakistan.
Pak J Pathol Jan ;12(4):34-6.

A 43 years old, otherwise healthy, male patient presented with a rapidly evolving fleshy nodular growth over his left forearm for the last three months. It started as a small asymptomatic firm growth that rapidly increased in size but produced only mild discomfort and tenderness on deep palpation. There was no history of ulceration or discharge from the growth and no associated lymphadenopathy. History of any preceding trauma or infection on the site of the lesion, or contact with tar and mineral oil was also lacking. Considering the rapid evolution and clinical presentation of the lesion a provisional diagnosis of Keratoacanthoma was made. Routine laboratory investigations were within normal limits. Histopathology of incisional tissue biopsy revealed keratin filled invagination of the epidermis into the dermis, marked inflammatory infiltrate comprising lymphocytes and plasma cells along with some nuclear atypia but no evidence of malignancy. These findings were consistent with the diagnosis of Keratacanthoma. The patient was observed for three months and since there was no sign of regression a surgical excision of the growth was advised. He was advised to report back one month after surgical excision but he failed to come for follow up.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com