Karamat Ahmed Karamat, Shahid Ahmad Abbasi, Tariq Butt, Masood Lqbal Satti, Nadeem Lkram.
In vitro efficacy of Teicoplanin against Methicillin Resistant Staphylococcus Aureus.
Pak J Pathol Jan ;12(2):15-8.

Methicillin resistant Staphylococcus aureus (MRSA) is one of the commonest nosocomial pathogens resulting in considerable morbidity and mortality in the hospitals. Most of the isolates are multiple drugs resistant and choice of antibiotics used against them is very limited. Vancomycin is the only available antibiotic to treat severe infections caused by these bacteria. There is, therefore, a need to introduce other antibiotics with similar or better spectrum of activity. Teicoplanin is claimed to have such properties. Two hundred isolates of MRSA were tested to determine in vitro efficacy of teicoplanin. Most of the isolates were from hospitalized patients having post operative infections. Modified Kirby - Bauer disc diffusion technique (NCCLS) was employed for the susceptibility testing. All the MRSA isolates were found to be susceptible to teicoplanin. This antibiotic is less toxic than vancomycin and promises to be a good alternative. However, clinical trials are required to determine the efficacy or otherwise of this antibiotic in vivo in our settings.

PakMediNet -Pakistan's largest Database of Pakistani Medical Journals - http://www.pakmedinet.com