Muhammad Usama Mazhar, Kaenaat Muneer, Fareeha Anwar, Waqar Ahmed Siddiqui, Aaminaquddus Qureshi, Rabiea Bilal, Bashir Ahmad.
In-vitro anticoagulant activity of three extracts of Astragalus sarcocolla.
Pak J Med Health Sci Jan ;14(2):393-6.

Aim: To access the anticoagulant effect of n-hexane (HE), chloroform (CE) and distilled water (DE) extracts of A. sarcocolla. Methodology: Resin of A. sarcocolla was extracted using n-hexane, choloform and distilled water using maceration. The extract was concentrated using rotary evaporator. Four different doses of extract (2.5, 5, 7.5 and 10 ug) were prepared for performing assay. In-vitro anticoagulant effects using human blood were studied in 42 healthy males age between 25-35 years. Results: All extracts significantly increased the PT in comparison to control. At highest dose of 10ug, with the exception of distilled water extract, all extracts demonstrated highly significant (p<0.001) increase in APTT. Conclusion: The data of the present study demonstrates that extracts ofA. sarcocolla possess anticoagulant activity.

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