Waqas Husain Qureshi, Zahid Sattar, Aakif Yousaf, Muhammad Ashraf, Akhtar Mahboob, Sajid Mukhtar.
Outcome of surgical procedures in patients suffering from perforated peptic ulcer disease.
J Allama Iqbal Med Coll Jan ;19(4):1008-11.

Objective: To investigate the mode of presentation and outcomes of surgical procedure along with prognosis of perforated peptic ulcer disease. Methods: Patients presented with peritonitis having history of peptic ulcer disease in outpatient or emergency department were enrolled in study. X-Ray abdomen and chest were obtained for all patients for diagnosis of pneumo-peritoneum. Primary repair and laparotomy was done for all patients and biopsy sample was taken. SPSS software was used to determine the statistical values of variable. P value ≤ 0.05 considered as significant. Results: In this study, 71.7% had perforated duodenal ulcer and 28.3% had perforated gastric ulcer with duodenal, 60% had previous history of peptic ulcer disease and 40% had history of taking NSAIDs. Pain in abdomen revealed in all the patients i.e. 100% patients. Vomiting, fever, constipation and abdominal distension were observed in 63.3%, 40%, 30% and 96.7%, respectively. Conclusion: Presentation of duodenal perforation is more common as compare to gastric perforation and more in male patients. Reason behind late presentation at health care facilities is unemployment and lack of education. Simple closure and Graham's patch give excellent results and associated with minimum mortality rate.

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