Rozina Khatoon, Habiba Sharaf Ali, Ome Kulsoom, Mehreen Yousaf Rana, Monika Maheshwari.
Impact of Myo-Inositol on Ovary and Menstrual Cycle in Polycystic Ovarian Syndrome (PCOS) - a Therapeutic Approach.
Pak J Med Dentistry Jan ;11(3):59-65.

Background: Women of reproductive age develop menstrual irregularities along with infertility because of polycystic ovary syndrome (PCOS); the most common endocrine disorder. Myo-inositol (MI) is found to have a proven role in the treatment of this disorder. The objective of this study was to determine the efficacy of Myo-inositol in regulating the menstrual cycle in women with PCOS. Methods: The study was conducted in 2019 at the Obstetrics and Gynecology department of Dr. Ziauddin Hospital Karachi with a sample of 50 women aged 18-45 years, having PCOS diagnosed with complaints of irregular menstrual cycles. Women with ovulatory dysfunction were excluded. Myo-inositol was given as 2 gm/day for 3 months. Pre- and post-trial data were collected, compared and analyzed through SPSS version 23 and a p-value <0.05 was considered statistically significant. Results: Mean +- SD age of participant women was 27.68 +- 4.787 years. The menstrual cycle duration increased from Mean +- SD 4.36 +- 2.22 to 4.70 +- 1.51 days after treatment with MI. The cycle flow increased from 19.10 +- 37.92 to 14.12 +- 13.34 ml (p-value < 0.001 each). Right and left ovary volume also decreased (p-value < 0.001 each) post-treatment. There were significant improvements in cycle flow severity towards normal pattern (from 14% to 80%; p-value < 0.001). The efficacy of Myo-inositol in regulating menstrual flow severity increased with decreasing age (p-value = <0.0001). Conclusion: Myo-Inositol was found efficacious in the treatment of PCOS and corrects menstrual irregularities, and menstrual flow, and normalizes ovarian volumes.

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