Tahira Mohammad, Muhammad Amjad, Aftab Akhtar, Tahir Aziz Ahmed.
A Rare Association of Anti- Gaba-B Receptor with Anti-HU Antibodies in Autoimmune Encephalitis: a Case Report.
Pak J Pathol Jan ;33(1):40-2.

Antibodies to the gamma-aminobutyric acid-B receptor (Anti-GABA-B-R) mediate an uncommon subtype of autoimmune encephalitis (AE) in which IgG antibodies directed against the B1 subunit of the GABA-B-R has been described. Clinically it presents as limbic encephalitis (LE) which is characterized by seizures, psychosis, and memory loss with progression to autonomic dysfunction, altered consciousness, and death. We present a case of an elderly male who presented in the ER due to progressive agitation, confusion, and irritability. Immunological workup revealed anti-GABA-B-R and anti-Hu antibodies. After admission, his consciousness rapidly deteriorated over the next few days, and he was intubated. The patient developed septic shock and due to poor prognosis, the patient`s family requested withdrawal of ventilatory support.

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