Aamna Latif, Rabia Latif, Uzma Ishaq, Sara Ali Zaidi, Nimra Anwar, Jahanzeb Malik.
Association of Age, Gender and Platelet Indices with Blood Cultures and Isolated Bacteria in Sepsis.
Pak J Pathol Jan ;33(1):14-9.

Objectives: Present study explored the association of sepsis with patients` age, sex and platelet indices [Platelet Count (PC),Mean platelet volume (MPV), MPV/PC)] with blood cultures and isolated bacteria. Material and Methods: Adult patients (18-70 years old) with clinically diagnosed "sepsis" and had at least one blood culture and complete blood count performed during January to September 2020 were included in this cross-sectional study conducted at a tertiary care hospital in Pakistan. Data was collected regarding patients` age, sex, platelet indices, blood culture and bacterial profile. Results: In 150 patients (79.3% females and 20.7 % males), Staphylococcus aureus was the most frequently isolated pathogen (52%) followed by Pseudomonas aeruginosa (12%). Chi-square test failed to reveal any association of gender (?2 0.33, p 0.6); age (?2 3.17, p 0.20); PC (?2 0.1, p 0.9); MPV (?2 2.36, p 0.30); MPV/PC (?2 0.02; p 0.9) with blood culture results. No association was found between gender (?2 0.68, p 0.4); age (?2 2.99, p 0.84); PC (?2 0.8, p 0.8); MPV (?2 0.98, p 0.75); and MPV/PC (?2 0.27; p 0.6) with isolated bacteria. Binary logistic regression showed that culture results and bacterial profile outcome cannot be predicted based on gender, age, PC, MPV or MPV/PC (p 0.50, 0.95, 0.83, 0.12, 0.84 and p 0.16, 0.12, 0.28, 0.43, 0.39 respectively). Conclusion: The predominant bacteria in our subjects was Staphylococcus aureus, followed by Pseudomonas aeruginosa. Blood culture results and bacterial profile are not associated with and cannot be predicted based on age, gender and platelet indices.

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