Muhammad Ali Khan, Agha Shabbir Ali, Afzal Rind, Fawad Hassan, Said Ul Haque.
Results of Muscle Biopsies from cases of Progressive Muscular Weakness.
Pak J Pathol Jan ;9(3):121-3.

This study was conducted at the Children`s Hospital & the Institute of Child Health, Lahore from Dec. 1996 to Nov. 1997 to look for the histological diagnosis of children presenting with progressive muscle weakness. Seventeen patients were included in the study. Open muscle biopsies were taken from calf, deltoid and vastus lateralis muscles according to the involvement of muscle groups. There were 13 males and 4 females. Biopsy specimens were stained with hematoxylin do eosin and read by senior histopathologisls. Muscular dystrophy was the most common diagnosis accounting for 10/17 (59%) cases. Duchenne muscular dystrophy was the commonest 8/10 followed by Fascioscapulo-humeral 1/10 and Limb Girdle type 1/l0. Myositis was the 2nd common diagnosis 4/17 (23.5%) comprising of polymyositis and dermatomyositis 2 each. Spinal muscular atrophy was seen in 3/17 patients. There is a need to develop better diagnostic fascilities and multidisciplinary approach toward these comes.

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