Nazia Iqbal, Waqar Muzaffar, Muhammad Haroon Sarfaraz, Saim Khan, Ubaid Ullah Yasin, Farooq-ul Abidin.
Efficacy of timolol maleate (0.5%) in preventing rise of intraocular pressure (IOP) post neodymium: yttrium aluminum garnet (nd: YAG) capsulotomy.
Pak Armed Forces Med J Jan ;72(1):255-59.

Objective: To determine the efficacy of 0.5% Timolol eye drops in preventing rise of intraocular pressure following Neodymium: Yttrium-Aluminum-Garnet laser posterior capsulotomy. Study Design: Quasi-experimental study. Place and Duration of Study: Outpatient Department of Ophthalmology, Combined Military Hospital Multan Pakistan, from May to Nov 2019. Methodology: Patients presenting with posterior capsule opacification, undergoing elective Neodymium: Yttrium Aluminum Garnet (Nd: Yag) Capsulotomy were enrolled in the study. Patients were alternatively assigned to two groups; group-1 was administered 0.5% Timolol Maleate eye drops, while group-2 was administered placebo natural team eye drops. Intraocular pressure for all the patients was measured at three-time points a). First measurement was baseline intraocular pressure at presentation/before the treatment. Second measurement was 1-hour post laser capsulotomy and third measurement was 3 hours post laser capsulotomy. Results: At 1-hour follow up, the mean intraocular pressure was significantly raised in the patients belonging to control group as compared to treatment group (21.45 ± 8.33 mm Hg vs 15.33 ± 3.37 mm Hg, p<0.001). At 3-hours follow-up the mean intraocular pressure decreased a bit for control group but still was significantly higher than the treatment group (17.40 ± 3.00 mm Hg vs 15.60 ± 2.30 mm Hg, p<0.001). Conclusion: Prophylactic use of Timolol successfully reduces the post-procedural acute rise in intraocular pressure due to Neodymium: Yttrium Aluminum Garnet laser posterior capsulotomy.

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