Ghulam Akbar Solangi, Bader Faiyaz Zuberi, Sikandar Shaikh, Wazir Muhammad Shaikh.
Pyrazinamide induced hyperuricemia in patients taking anti-tuberculous therapy.
J Coll Physicians Surg Pak Jan ;14(3):136-8.

Objective: To record the effect of pyrazinamide on uric acid in patients of tuberculosis. Design: Descriptive and observational study. Place and Duration of Study: Chandka Medical College Hospital, Larkana from February 2000 to January 2003. Patients and Methods: All patients receiving anti-tuberculosis drugs with pyrazinamide were included. Serum uric acid levels were monitored at weeks 0, 2, 8 and 12 of therapy. Serum creatinine was done at weeks 0, 8 and 12. Results: Results were reported on 216 patients. Mean uric acid and creatinine levels at the start of therapy, i.e., week `0` were 5.07 ±0.57 mg/dl and 0.87 ±0.11 mg/dl respectively. The results show significant increase in uric acid levels from week `0` to week `2`, at the end of week `8`, the levels remained elevated and there was no statistical significant difference from that at week `2`. The uric acid levels reduced at week `12` after pyrazinamide was stopped and the difference was significant. Despite that renal function steadily improved with the treatment of tuberculosis to the extent that comparable pre-treatment values were obtained at the end of treatment. Conclusion: Anti-tuberculous therapy with pyrazinamide affects the uric acid levels early. This change is reversible after the withdrawal of the agent.

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