Rimsha Iram, Iqra Akram, Bushra Anwaar, Anum Farooq.
Fabrication and characterization of fast dissolving films of H2-receptor antagonist.
J Contemporary Pharm Jan ;3(1):7-11.

Objective: The aim of the present study was to develop a fast dissolving film (FDF) of taste masked inclusion complex of Famotidine (FMT) using film forming polymer. Method: FDFs were prepared by solvent casting method. The developed FDFs were characterized for film thickness, disintegration time, flexibility, dissolution study. The developed FDFs of FMT were transparent, elegant, smooth and homogenous. Results: Physico chemical characterization of FDFs showed no interaction between the drug and film forming polymer. The drug content was found in the range of 96.05 to 102% and disintegration time was found in pharmacopoeia limit, which was less than1 min. In vitro drug release study showed that approximately 82% drug release within 60 sec. Conclusion: Fast Dissolving film of famotidine is prepared that dissolve within one minute when placed on tongue. It gives fact action because it avoids the first pass metabolism. These films are preferred in geriatric and pediatric patients.

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