Mamoora Mirza, Nasim Karim, Wahab Baksh Kadri, Shama Asghar.
Clinical efficacy of 1% metformin gel and systemic doxycyline in chronic periodontitis: a randomized clinical trial.
J Liaquat Uni Med Health Sci Jan ;20(3):204-8.

OBJECTIVE: To compare and evaluate the clinical efficacy of 1% Metformin gel and oral Doxycycline in adjunct to SRP on clinical and biochemical parameters in patients having localized moderate chronic periodontitis. METHODOLOGY: This randomized open-label clinical trial was held at Bahria Dental College Hospital by convenient sampling technique from October 2019 to March 2020. Sixty systemically healthy, males and females aged 30-50 years, diagnosed with localized moderate chronic periodontitis were enrolled. Molars with deepest PPD, CAL, PI, and mSBI were included. Patients with a history of periodontal therapy and mouthwashes were excluded. Patients were divided randomly into two groups with 30 in each. Group A had SRP and Doxycycline and Group B received Metformin 1% gel intra-pocket with SRP at day 0. Clinical parameters were evaluated on days 0, 45, and 90. TNF? was evaluated on days 0 and 90. Results were statistically analyzed using SPSS software version 23. RESULTS: Group B showed a significant reduction in PPD and CAL compared to group A while PI and mSBI were found non-significant. TNF? was significantly reduced in group B on day 90. CONCLUSION: 1% Metformin intra-pocket gel has produced more beneficial effects on clinical and biochemical parameters in comparison to conventional Doxycycline in adjunct to SRP in localized moderate chronic periodontitis. KEYWORDS: Chronic periodontitis, Doxycycline, Efficacy, Local delivery, Metformin gel, TNF?

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