Saman Iqbal, Natasha Bushra, Lamia Yusuf, Taseer Fatima, Sana Ishfaq.
Comparison of Ondansetron versus Metoclopramide for the Management of Females Presenting with Hyperemesis Gravidarum.
J Sharif Med Dent Coll Jan ;08(1):17-21.

Objective: To compare the outcome of ondansetron versus metoclopramide for the management of females presenting with hyperemesis gravidarum. Methodology: It was a quasi-experimental study conducted in the Department of Gynaecology & Obstetrics, Services Hospital, Lahore. The study was completed in the period from March to August 2020. Patients diagnosed with diabetes mellitus, hypertension, multiple gestations, and allergic to medication were excluded from the study. The study comprised 60 participants who were divided into two groups. In the ondansetron group, females were given a single dose of 4 mg ondansetron diluted in 100 mL of normal saline. In the metoclopramide group, females were given a single dose of 10 mg metoclopramide diluted in 100 mL of normal saline. After 24 hours, females were asked for any episode of vomiting and nausea score. Data was analyzed using Statistical Package for the Social Sciences (SPSS) version 22. Results: Out of 60 females included in the study, 30 were enrolled in each group. In the ondansetron group, vomiting was found in 13(43.3%) patients in the last 24 hours after administration of the drug. In the metoclopramide group, episodes of vomiting were found in 19(63.3%) patients within 24 hours after administration of metoclopramide. The difference between the two study groups was not statistically significant (p-value=0.121). The mean nausea score was 6.70+/-1.09 in subjects who took ondansetron while in patients who were given metoclopramide, the score was 6.40+/-1.33. This difference was also not significant (p-value=0.343) in the metoclopramide group. Conclusion: Both ondansetron and metoclopramide are equally effective for the management of females presenting with hyperemesis gravidarum. Keywords: Hyperemesis gravidarum. Ondansetron. Metoclopramide.

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