Farah Khan, Sehrish Khurshid, Saira Jamshed, Ayesha Kashmala Ghauri, Arif Memon, Noureen Waleem.
Prevalence of epithelial cell abnormality in Pap smear.
Pak J Surg Jan ;38(1):41-4.

Background: Cervical cancer is the most common gynecological malignancy in female and it is the leading cause of high mortality among female in Pakistan. Pap smear is an effective screening tool for early detection of pre-malignant and malignant lesion of cervix. Objective: To determine prevalence of epithelial cell abnormality in Pap smear Place of study: Hamdard University Hospital, Department of Obstetrics and Gynecology and Histopathology department. Material and Methods: A retrospective study was conducted at Hamdard University Hospital, Karachi from June 2020 to June 2021. A detailed history and examination was done and an informed consent was taken before the procedure of Pap smear. Aft er collection of smear it was gently spread on glass slide and glass slide was placed in jar containing formalin. Slide was stained Cytological interpretation was done by microscopic examination in histopathology department. Results: Total 200 cases were included in the study who undergone the procedure of Pap smear. The age range of patients were 20-65 years with mean age of 41.3. Out of 200 cases 172(86%) were negative for intraepithelial lesion and 23(11.5%) were positive for squamous cell abnormalities. Inflammation was the most common cytological abnormality. 142(71.0%) cases were reported as inflammation and infection. Atypical squamous cell abnormality is seen in 10(5.0%) cases. Low-grade squamous intraepithelial lesion (LSIL) was present in 8(4.0%) cases. High-grade squamous intraepithelial lesion (HSIL) was present in 5(2.5%) cases. Conclusion: Pap smear is an effective screening tool to detect premalignant and malignant lesion.

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