Hafiza Hina Pasha, Ayesha Sadiqa, Sauda Usmani, Saima Tabassum, Hamid Javaid Qureshi.
Correlation of Serum Adiponectin with Lipid profile in Diabetic and Non Diabetic Rats.
Esculapio J Services Inst Med Sci Jan ;15(3):203-5.

Objective: We intended to determine the relationship of adiponectin with lipid profile in diabetic and non-diabetic rats. Methods: A randomized controlled trial (RCT) study was conducted at Physiology department, Services Institute of Medical Sciences (SIMS), Lahore from August 2013 to January, 2014. This study was conducted on sixty male albino rats weighing 150-200gm. Thirty rats were selected after induction of diabetes with alloxan monohydrate (group B). Another 30 non diabetic healthy rats were chosen and labeled as group A. A 4-5 ml intracardiac blood sample was taken from each rat. Biochemical parameters evaluated were adiponectin (by ELISA method), serum total cholesterol (by CHOD-PAP enzymatic colorimetric method), serum triglyceride (by GPO-PAP enzymatic colorimetric method), serum HDL-C (by Precipitation method) and serum LDL -C (by using Friedewald fomula, LDL=TC- (HDL+TG/5). Results: There was a significant negative (r= -.404, p=.027) correlation of serum adiponectin with serum triglyceride in diabetic group. Serum VLDL also showed a significant negative (r= -.404, p=.027) correlation with serum adiponectin in diabetic group. No significant correlation was found between serum adiponectin and lipid parameters in non-diabetic group. Conclusion: The negative correlation of serum adiponection with serum triglycerides and VLDL in diabetics depicts its association with insulin resistance in type 2 diabetics.

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