Aisha Abdul Haq, Sadia Afzal, Rabia Rehan, Maria Khan, Hira Ahmed, Sadia Iqbal.
Chemotherapy: Affected Morphological and Morphometry of Testes and Improvement by Antioxidants.
J Saidu Med Col Jan ;12(4):174-8.

Background: Taking into account, the adverse effects of chemotherapy on male fertility, Chemotherapy has been a major area of concern for physicians. Chemotherapeutic agent Doxorubicin (DOX) profoundly affect the morphometric of testes that is indicative of damage to this important reproductive organ. Antioxidants being free radical scavenger could be used in order to ameliorate the Undesirable effect of anti-cancer agents Objective: To demonstrate change in weight of testes and thickness of germinal epithelium after consumption of Doxorubicin and to observe the effect of ascorbic acid on these changes Material and Methods: Experimental study was conducted on mice which were divided in 3 groups A, B and C. They received saline intraperitoneally (IP), DOX IP and DOX + Ascorbic acid per oral respectively. On completion sacrificed animals were dissected and testes were weighed and later sections were selected for morphometric measurement of germinal epithelium and were observed in H&E stained slides under 40x objective and 10x ocular lenses of light microscope Result: Ascorbic acid seems to be significantly affecting the declined weight of the organ and on disturbed morphometry of germinal epithelium in mice induced with chemotherapeutic agent DOX Conclusion: Ascorbic acid seems to be significantly affecting the declined weight of the organ and on disturbed morphometry of germinal epithelium in mice induced with chemotherapeutic agent DOX Keyword: Chemotherapy, antioxidant, weight, germinal epithelium, mice.

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