Boshtam M, Sarraf, Rafiei M, Naderi G A, Samarian H.
The relation between Creatine Kinase, Magnesium and Fibrinogen in patients with acute Myocardial Infarction.
Pak J Cardiol Jan ;10(2-3):47-53.

One of the most important mechanism of myocardial infarction is coronary thrombosis. One of the diagnostic procedures for myocardial infarction (MI) is serological tests to determine the levels of creatine kinase enzyme (CK) and, more effectively, creatine kinase MB isoenzyme (CK-MB). On the other hand, high serum fibrinogen concentration can be considered as a risk factor for MI or the occurrence of complications after MI. The present study was conducted to find any possible relationship between the serum CK and CK-MB levels with serum magnesium and fibrinogen concentrations in acute MI (AMI), as well as any association between each of the factors mentioned with post-MI complications. The study included 100 MI affected patients (60 men and 40 women, between 30-60 years) hospitalized in the coronary care units (CCUs) of Isfahan hospitals in 1995. A questionnaire was completed for each subject to obtain information on personal characteristics, previous history of cardiovascular disease risk factors, MI type and location, radiological symptoms, prescribed medicines, and ..., in addition daily electrocardiography was performed for all patients. Also, blood samples were taken from each patient on admission, 6, 24 and 48 hours after MI for serum CK and CKMB measurements; the serum magnesium and fibrinogen concentrations were measured on the first and the second days, respectively. The results show that the peak value for CK enzyme and isoenzyme occurs 24 hours after MI. As regards the correlation between the serum magnesium and fibrinogen levels with the CK enzyme and CK-MB isoenzyme concentrations at different time points after MI, a significant correlation was observed only after 24 hours. The serum fibrinogen concentration was higher in men (366±103.7) than in women (311±105.2) (p=0.05). On the other hand, the mean value of CK-MB isoenzyme was significantly higher in the Q-wave MI patients than in the non-Q-wave ones 6 and 24 hours after MI. In addition, there was a significant correlation between the CK enzyme and CKMB isoenzyme levels with post-MI complications after 24 hours. No correlation was found between serum magnesium and enzyme or the occurrence of MI complications were observed. It is concluded that only serum fibrinogen concentration can be used as a diagnostic serum marker for complicated MI.

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