Shamas Un Nisa, Rukhsana Aziz, Tahira Nazir, Khadija Sundas, Ayesha Amin, Abdul Ahad.
Comparison of vaginal progesterone plus cervical cerclage versus vaginal progesterone alone in reducing preterm birth in high risk women..
Professional Med J Jan ;30(8):982-7.

Objective: To compare the outcome of vaginal progesterone plus cervical cerclage versus vaginal progesterone alone in reducing preterm birth in high risk women. Study Design: Randomized Controlled Trial. Setting: Department of Obstetrics and Gynaecology, Bahawal Victoria Hospital, Bahawalpur. Period: April 2022 to October 2022. Material & Methods: A total of 330 high risk women aged between 18-40 with sonographically short cervix (<25 mm) were included. After randomization, in Group-A (n=165), cervical cerclage was done at 12 weeks and then 200 mg vaginal progesterone was given once daily at night till delivery while in Group-B (n=165) women, 200 mg vaginal progesterone was given once daily at night till delivery. All women were followed up till delivery and outcome (satisfactory/unsatisfactory) was noted. Results: In a total of 330 women, the mean age was 29.17±5.29 years while 194 (58.8%) women were aged between 18 to 30 years of age. Satisfactory outcome (no preterm birth in <37 weeks) was seen in 151 (91.5%) women in Group-A (combination of vaginal progesterone plus cervical cerclage) and 102 (61.8%) in Group-B (vaginal progesterone alone, p=0.0001. Conclusion: This study concluded that outcome of combination of vaginal progesterone and cervical cerclage is better as compared to progesterone alone in reducing preterm birth among high risk women.

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