Nadeem Ikram, Khalid Hassan, Khalid Bukhari.
Spectrum of hematological lesions amongst children, as observed in 963 consecutive bone marrow biopsies.
J Pak Inst Med Sci Jan ;13(2):686-90.

This paper details the spectrum of hematological lesions, as depicted by consecutive 963 bone marrow biopsies performed over a period of five years in children (less than 15 years age) at Rawalpindi Medical College. Iron deficiency concomitant with megaloblastic anaemia was the commonest hematological finding (29.7%), followed by megaloblastic anaemia alone (11.9%) and iron deficiency alone (10.5%), respectively. As a whole, deficiency anaemias contributed 52.1% of cases. Other hematological lesions, in descending order of frequency, were leukemias (10.4%); Idiopathic thrombocytopenic purpura (5.7%); anemia due to underlying disorder (5.1%); severe aplastic anaemia (4.9%); myeloid hyperplasia (4.5%); Visceral Leishmaniasis (4.4%); haemolytic anaemias (3.1%) malaria (1.9%); Non - Hodgkin`s lymphoma (1.87%); isolated megakaryocytic depression (1.5%); leukaemoid reaction (1.0%); pure red cell aplasia (0.9%); lipid storage diseases (0.7%); hypersplenism (0.6%); sideroblastic anemia (0.5%); Hodgkin`s lymphoma (0.4%) , congenital dyserythropoietic anemia and Letterer Siwe disease (0.3%) each, respectively. Consanguinity, poverty, malnutrition and environmental exposure can be assumed as causation in many of the above diseases.


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