Subeeka Nadeem, Sumera Mahar, Sawera Rafique, Fasiha Sohail, Misbah Jawed, Mehma Akhter Anwer, Maria Ali.
Role of Leukocytes Ratio in Predicting Survival with COVID-19.
Pak J Med Dentistry Jan ;12(2):50-5.

Background: Eosinophils, the main cells in the immune system, play a key role in parasitic and allergic diseases. However, their role in viral infections is still a matter of debate. Therefore, this study was conducted to evaluate the eosinophils, eosinophils to lymphocyte ratio, and lymphocyte to monocyte ratio in predicting survival in COVID-19 patients. Methods: This retrospective study was conducted in the COVID-19 ward from August 2021 to January 2022. A total of 497 diagnosed patients of Covid-19 disease were enrolled aged >25 years of both genders. Quantitative variables were presented as percentages and frequencies. The Chi-square test was applied to evaluate the association. Results: Of 497 patients infected with Covid-19, 311 (62.6%) were males and 186(37.4%) were females. The mean value of eosinophils was 0.52 +- 1.27 and the eosinophils to lymphocyte ratio (ELR) was 0.05 +- 0.11. The association of age and hematological parameters with gender was found at 52.25 +- 27.52 years in males and at 55.20 +- 25.77 in females (p=0.114). In addition, the mean value of ELR was observed 0.05 +- 0.11 in males and 0.04 +- 0.11 in females (p=0.627), whereas, mean lymphocyte to monocytes ratio (LMR) was 2.44 +- 2.07 in males and 3.21 +- 5.02 in females (p=0.011). Conclusion: A significant association was reported in the lymphocyte-to-monocyte ratio (p < 0.011) in both genders, whereas an insignificant association was found in Eosinophil to lymphocyte ratio. Thus, LMR, ELR, and CRP levels may be effective markers for survival in Covid-19.

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