Naveed Gul, Kashif Ramooz, Yasir Shehzad, Soban Sarwar Gondal, Fraz Mehmood, Hafiz Muhammad Ali Khan, Eesha Yaqoob, Saad Javed.
The Lower-Back Painkiller Challenge: Efficacy of Tramadol Versus Tapentadol.
Pak J Neuro Surg Jan ;27(3):156-63.

Introduction: To reduce pain levels in people with lower back pain, the study looked at the comparative efficacy and tolerability of Tramadol and Tapentadol taken by oral route. Materials & Methods: This comparative study consisted of a total of 126 patients divided into 2 groups, the Tapentadol and Tramadol groups for managing low back pain. Participants aged 18-60 with moderate or higher pain intensity were included. Data on pain intensity, adverse events, and patient-reported outcomes were collected at baseline, day 7, and day 14. Participants were randomly assigned to Tapentadol or Tramadol groups, receiving respective medications for 14 days. Data analysis involved t t-test to compare groups. Means and SD were also calculated. Results: The mean age of the patients in the Tramadol group was 33.1 +- 19.1 and in the Tapentadol group was 37.6 +- 19.9, respectively. Sixty of the total participants were men and sixty-five were women. Participants were split equally between groups A and B, with 30 men and 33 women in group A and 30 men and 32 women in group B. The findings demonstrated that both medications considerably lessened moderate to severe chronic lower back pain (CLBP) patients` pain levels. At 28 days after the baseline, the mean VAS scores for groups A and B were 34.57 and 37.55, respectively. Conclusion: According to the study`s findings, these two medications effectively reduce pain in those with chronic lower back pain. Tapentadol is observed to be tolerated well and more effective than Tramadol.

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