Burhan Ahmad Khan, Azhar Mahmood Qureshi.
Pathogenesis and management of Chronic Myeloid Leukaemia.
J Pak Inst Med Sci Jan ;14(1):754-67.

Chronic myeloid leukaemia (CML) is a clonal myeloproliferative disease characterized by a proliferation of myeloid cells without loss of the capacity to differentiate unlike acute leukaemia.) Cytogenetic and isoenzyme studies have proved that this is a clonal haematopoietic stem cell disorder arising from a single cell). This altered stem cell proliferates and generates a population of differentiated cells that gradually replaces normal haemopoiesis and leads to a greatly expanded total myeloid mass.

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