Ather Muneer, Hina Saghir, Mariam Tariq, Ambreen Zahoor, Hafiz-ud Din.
To Determine the Relationship of Neutrophil/Lymphocyte Ratio (NLR) and Platelet/Lymphocyte Ratio (PLR) as Inflammatory Markers with Manic Episode of Bipolar Disorder Type I.
J Islamic Int Med Coll Jan ;18(4):252-6.

Objective: To investigate neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) as inflammatory markers in bipolar disorder type I patients with 1 episode and recurrent mania. Study Design: An observational, cross-sectional study. Place and Duration of Study: The study was conducted in HBS General Hospital, the tertiary care teaching hospital of HBS Medical & dental College, a private medical college located in Islamabad. The duration of study was from 01/11/2022 to 30/04/2023 for a period of 6 months. Materials and Methods: Forty cases were recruited by consecutive sampling, comprising of 20 1 episode mania and 20 recurrent mania and these were compared to 20 healthy controls (HC). In the patients Young Mania Rating Scale was used to assess the severity of mania. Samples for blood counts were obtained from all the participants in the morning hours. Results: Compared to HC, both 1st episode and recurrent mania patients had significantly higher neutrophil and NLR values, and lower lymphocyte counts. When the two patient groups were compared, first episode mania cases had significantly higher neutrophil counts and NLR than patients with recurrent mania. Conclusion: The findings of the study showed a likely inflammatory pathophysiology in the manic phase of BD. Since 1st episode, drug naive mania patients had greater inflammation as compared to recurrent mania cases, it was conceivable that psychotropic medicines exerted an anti-inflammatory effect in the latter group.

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