Nida Rasheed, Sarah Ghafoor.
Commiphora wightii and molmol have therapeutic effects in oral cancers and COVID-19 disease by modulating anti-apoptotic proteins and inflammatory pathways.
Biomedica Jan ;38(4):193-7.

Oral squamous cell carcinoma (OSCC) has become prevalent worldwide and is one of the leading causes of death. Derangement of anti-apoptotic proteins is important regarding OSCC development. Over-expression of these proteins leads to prolonged cellular survival, thus increasing the susceptibility of tumor formation. Commiphora wightii and molmol are the natural herbs with ability to downregulate anti-apoptotic proteins by acting on nuclear factor-kappa B (NF-κB) pathway, p53 pathway, signal transducer and activator of transcription pathway, estrogen, cyclooxygenase 2, and mitogen-activated protein kinase pathway. NF-κB pathway has been found to involve in the release of cytokine storm associated with COVID-19 disease. Commiphora wightii and molmol suppress the COVID-19 infection by their anti-inflammatory and anti-viral properties. This review sheds light on the effect of C. wightii and molmol on suppression of oral cancer and COVID-19 infection by modulation of anti-apoptotic proteins and inflammatory pathway.

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