Aafrinish Amanat, Sadaf Waris, Nadia Wali, Sadia Alam, Atika Masood, Maleeha Aslam.
Determination of Estrogen Receptor, Progesterone Receptor & Human Epidermal Growth Factor Receptor 2 Status in Breast Cancer: a Single-Center Experience.
J Sharif Med Dent Coll Jan ;8(2):47-51.

Objective: To determine the frequency of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expressions and to compare them with certain morphological parameters of breast tumors. Methodology: It was a retrospective record-based study carried out in the Pathology Department of Akhtar Saeed Medical & Dental College, Lahore. A total of 45 cases of breast cancer from January 2021 to May 2022 were included in this study. The cases included needle core biopsies and mastectomy specimens. The sections were processed and examined under a microscope. Grading of tumors was done by the Bloom Richardson grading system and tumor characteristics for mastectomy specimens such as tumor size and lymph node status were noted. The luminal classification was done and frequencies were calculated. The immunohistochemical analysis was performed for estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). Scoring was done according to the breast cancer template of the College of American Pathologists. The frequencies were calculated for ER, PR, and HER2 status, Bloom grades, and tumor characteristics. Results: In our study, the mean age of the patients was 46.31 years and most of the cases were seen in the age group of 55 to 64 years. The frequency of ER-positive cases was 29(64.4%) while the frequency of ER-negative cases was 16(35.6%), the frequency of PR-positive cases was 19(42.2%), and PR-negative cases was 26(57.8%). In contrast, the frequency of HER2-positive cases was 13(28.9%) and the frequency of HER2-negative cases was 28(62.2%). Most ER-positive cases were observed in the age group 45 to 64 years and most of the HER2-negative cases were seen in the age group 55 to 64 years. The majority of the cases (95.6%) were invasive ductal carcinoma. Most of the cases of breast cancer were of grade II (87%) and luminal A type (40%) was the most frequent one. In the mastectomy specimens, the size of the tumor in most of the cases (55.6%) was 2 to 5 cm and a majority of the cases (33.3%) had >=4 lymph nodes positive. Conclusion: Estrogen receptor was most frequently expressed along with loss of HER2 receptor. Invasive ductal carcinoma was the most common histological type and the majority of breast cancer cases showed grade II. The most common type of carcinoma was the luminal A type. Keywords: Breast carcinoma. Estrogen receptor. Progesterone receptor.

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