Mariam Saeed, Muhammad Zeeshan Rana, Najeebullah Khan, Hina Anwar, Shakeel Ahmed.
Reference range of NT pro BNP in healthy pregnant females.
Pak J Pathol Jan ;34(3):79-83.

Objective: To define the Reference Range of NT pro-BNP (N-terminal pro-B-type natriuretic peptide) during the first trimester of pregnancy in healthy females. Material and Methods: This Cross-sectional study was conducted in the Department of Chemical Pathology, Combined Military Hospital, Lahore from September to November 2022. This cross-sectional study focused on the reference range of NT pro-BNP in healthy pregnant females. Sampling of the data was done by using the nonprobability consecutive sampling technique. A maximum number of available participants (365 pregnant females) during the study period were recruited. Descriptive statistics were shown as mean +- SD. For the reference range for NT pro-BNP 2.5th percentiles (lower limit) and 97.5th percentiles (upper limit) were estimated. Results: A total of 365 pregnant females were included with first trimester pregnancy, having the mean age 28.54 +- 5.18 years. Out of 365 participants, 299 females had BMI <25 whereas 66 were overweight. Forty-One females had Hb level <= 10 g/dl and 324 females had HB >10 g/dl. The Platelet count was >150 x 10^9/L in 338 women, and <=150 x 10^9/L in 26 women. The Median of NT pro-BNP was 56.80 pg/mL in the first trimester. Reference range of NT pro-BNP in pregnant women with BMI <25 was (17.89 - 257.00) pg/mL as compared to (16.88 - 130.63) pg/mL in those with BMI >25. Conclusion: The Reference range of NT pro-BNP changes in pregnancy as compared to healthy non-pregnant adults, likely due to hemodynamic changes associated with pregnancy. This study has defined a Pregnancy-specific reference range of NT pro-BNP in the first trimester which can help diagnose pregnant women with underlying cardiovascular disease.

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