Imdad Hussain, Qammar Jamal.
Immunohistolocalization of c-erbB-2 protein: A proliferative marker in benign prostatic hyperplasia.
Pak J Med Sci Jan ;20(3):234-7.

Objective: To examine possible role of c-erbB-2 in the development of benign prostatic hyperplasia. Design: A retrospective study of 25 patients suffering from benign prostatic hyperplasia. Setting: BMSI, Jinnah Postgraduate Medical Centre, Karachi. Subjects: Twenty five patients between the ages of 51-80 years were selected for the period of 2001 suffering from benign prostatic hyperplasia. Results: Results of study show that overall frequency of c-erbB-2 expression was not found. Maximum numbers of BPH among total cases were in age group 61-70 years i.e 13 tumours (52% of total cases). Conclusion: Results of current study and work of previous researchers indicate a lot of controversy over c-erbB-2 immunostaining in benign prostatic hyperplasia. Further study is required to elucidate the precise role played by this protein marker in the benign growth of prostatic tissue.

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