Aqsa Mushtaq, Muhammad Younas, Zujaja Hina Haroon, Muhammad Usman Munir, Sayed Tanveer Abbas Gilani, Muhammad Anwar.
Evaluation of Apolipoprotein B / Apolipoprotein a Ratio as an Alternate of Lipid Profile for Cardiovascular Risk Assessment in a Tertiary Care Hospital.
J Islamic Int Med Coll Jan ;19(1):5-9.

Objective: To compare the predictive utility of serum Apo B/Apo A ratio with serum lipid profile in evaluation of cardiovascular disease (CVD) risk assessment. Study Design: Cross sectional study. Place and Duration of Study: Research was done at Department of Chemical Pathology & Endocrinology, Armed Forces Institute of Pathology (AFIP), Rawalpindi from 1 January 2021 to 31 March 2022. Materials and Methods: A total of 204 patients were enrolled from a tertiary care hospital admitted for recent cardiac events and were compared with 96 healthy individuals. A serum sample was taken from all the members of both groups. Their lipid profile, Apo A, and Apo B were analyzed. Apo B/ Apo A ratio was calculated. The data was analyzed using SPSS version 21. Results: Means of patient group for total cholesterol, LDL-cholesterol, HDL-cholesterol, VLDL-cholesterol, triglycerides, and Apo B/Apo A ratio were 4.18 +- 1.21, 2.52 +- 1.06, 0.83 +- 0.34, 0.71 +- 0.31, 1.66 +- 0.86, 0.96 +- 0.60 respectively, whereas means for control group were 3.99 +- 0.54, 2.31 +- 0.56, 1.00 +- 0.31, 0.59 +- 0.15, 1.22 +- 0.33 and 0.70 +- 0.18 respectively. Independent t-test was applied to compare means between two groups, which showed statistically significant difference between Apo B/Apo A ratio, HDL, and TG (p value <0.001). Chi-square test was applied for comparison of two groups which was statistically significant (p value <0.001).Conclusion: Apo B/Apo A ratio is a better indicator for evaluation of cardiovascular disease as compared to lipid profile suggesting it to be a new and robust marker for CVD risk evaluation in our population.

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