Muhammad Naeem.
The role of radical radiation therapy in the treatment of invasive bladder cancer.
Pak J Med Res Jan ;39(3):123-6.

Outcome of 20 patients who received definitive radiotherapy for invasive transitional cell carcinoma of urinary bladder is presented. All the patients had T2-3 stage of primary tumour as assessed by ultrasonography, intravenous urography, computed tomography, X-ray chest, cystoscopy, bimanual examination, biopsy/resection and histopathology. Mean dose of radiation was 6570 cGy (range 5800-7000 cGy ). three patients (15%) lost follow up. Nine patients (45%) died within 3 years of radiation therapy. Four patients (20%) are alive for more than 5 years. Four patients (20%) underwent salvage cystectomy within 2 years after radiotherapy because of radiation associated complications. Two out of these 4 patients died postoperatively and 2 are alive for more than 3 years after salvage cystectomy. Though this is a small series, the results are comparable with other reports in literature. Conclusion: 1. Though sample of our study is small, 5 years survival rate is similar to other studies reported in literature. 2. Definite protocols for management of invasive bladder cancer should be made with proper follow up and more comprehensive studies should be done.

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