Ahmed Z, Shah H U, Yaqoob N, Muzaffar S.
Pleomorphic Liposarcoma in a ten year old Child.
J Pak Med Assoc Jan ;54(10):533-4.

We received the specimen of a ten year old boy from Nawabshah coded as "mass left lower leg". There was a history of trauma a month ago which was followed by the development of a mass along with a non-healing ulcer opening on the surface of the skin, on the lateral aspect of the left lower leg. Interestingly, provisional clinical diagnosis was giant cell tumor of bone. Grossly, the specimen consisted of multiple nodular soft tissue fragments measuring together approximately 12x8.5x6cms in aggregate. Multiple representative sections from the soft tissue fragments were submitted. On microscopy, the tumor was seen to be composed of sheets of malignant lipoblasts with highly vacuolated cytoplasm and severe nuclear hyperchromasia. Bizarre tumor giant cells were seen and numerous mitotic figures including abnormal ones were identified. In many cells, the nuclei were indented due to the presence of intracytoplasmic lipid. On immuno histochemistry, the tumor cells were positive for S100 protein and weak positive for vimentin. Tumor cells were negative for cytokeratins, anti smooth muscle actin and CD34. Based on the histological features, a diagnosis of pleomorphic liposarcoma was made.

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