Mohammad Shoaib Randhawa.
Mitral Regurgitation following first time acute Myocardial Infarction: Early and late echocardiographic evaluation.
Pak J Med Sci Jan ;20(4):319-24.

Objective: To compare the prevalence of mitral regurgitation in patients with first time acute myocardial infarction before hospital discharge and after two months follow up and its significance. Design: Prospective analysis of sixty patients presenting with first time acute myocardial infarction with age matched controls. Setting: Department of Medicine and Coronary Care Unit, postgraduate Medical Institute, Services Hospital, Lahore. Main Outcome Measures: Regurgitant flow area and flow velocity, left ventricular dimension, AV displacement, Chamber size. Results: Baseline clinical and Echocardiac data was not significantly different from age matched controls at presentation, Left ventricular internal dimension. During systole and diastole phases were 38± 4mm and 52±2 to 36±3mm and 50±1 mm respectively. However at 2 months follow up these dimensions increased to 40± 2 mm and 56± 2 mm respectively. Mean atriovantricular plane displacement in healthy control and the patients were15±1 mm and 11±2 mm respectively. Prevalence of Doppler detected mitral regurgitation in healthy subjects was 25% as compared to 65.2%of the patients at 2 months follow up. Regurgitation flow area in these patients was 1.02±1.2 cm2 from baseline to1.13±1.2cm2 after 2 months follow up occupying 7.2±7.3% to 8.3±6% of the left atrial area respectively. Conclusions: Prevalence of Doppler detected regurgitation of weak intensity in our study is 25%,: It rose to 65.2% following first time acute myocardial infarction but mild in majority of the patients and remained insignificant after two months follow up. Echocardiographic significant mitral regurgitation was present in only 3 patients(6.52%)

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