Mohammad Ishaq.
Is combining Angiotensin Converting Enzyme (ACE) inhibitor with Angiotensin II receptor blockers (ARB) beneficial?.
Pak Heart J Jan ;35(1-4):37-8.

Interest has grown recently in the use of ACE inhibitors and ARBs in combination. The rationale behind this dual blockade of RAS lies in the fact that ACE inhibitors only partially block the RAS and physiologically active levels of angiotensine II persist despite long term therapy with ACE inhibitors. (6) In addition to this the ACE inhibitors also have effects on Bradykinin which are not shared by ARBs. In contrast the ARBs offer more complete blockade of RAS and therefore avoids the phenomenon of so called `partial escape` seen with ACE inhibitors. This is a review article.

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