Shaikh Sajjad Ahmed, Saleem Ahmed Kharal, Muhammad Sabir, Rizwana Barakzai, Shazia Asad.
Is Vancomycin the only choice for Methicillin Resistant Staphylococcus Aureus? Results from a multi-centered study on antibiotic sensitivity pattern of Staphylococcus Aureus isolated from nosocomial infections.
Ann Abbasi Shaheed Hosp Karachi Med Dent Coll Jan ;8(1):16-25.

Objective: To observe the pattern of antibiotic resistance in methicillin sensitive and methicillin resistant staphylococcus aureus. Materials and Methods: Two hundred Staphylococcus aureus isolates from patients with hospital- acquired infections were collected. Methicillin resistance was determined by disc (oxacillin 1 µg) diffusion method. Sensitivity to other antimicrobial agents was determined by Kirby Baurer disc diffusion method. Results: The methicillin resistant Staphylococcus aureus isolates were found sensitive to vancomycin (100%), fusidic acid (88.5%), chloramphenicol (80.8%) and fosfomycin (61.5%). All the isolates were highly resistant to other classes of antimicrobial agents. Conclusion: Methicillin resistant Staphylococcus aureus shows multi-drug resistance and infections caused by these isolates are difficult to treat. However our results show that beside vancomycin; fusidic acid, chloramphenicol and fosfomycin are good choices and should be tried for the isolates showing sensitivity to these agents.

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