Iqbal Hussain Udaipurwala, Muhammad Shafique Soomro.
Use of antibiotic in Tonsillectomy: is it really beneficial?.
Med Channel Jan ;10(3):17-20.

OBJECTIVES: To assess the effectiveness of prophylactic antibiotic in reducing post-tonsillectomy morbidity in our local setup. Secondly, two different groups of antibiotics (amoxicillin/ clavulanic acid and cefaclor) were also compared for its efficacy in reducing post-tonsillectomy morbidity STUDY DESIGN: A prospective experimental and comparative study. PLACE & DURATION OF STUDY: This study was conducted at Jinnah Medical College Hospital, Karachi over a period of more than four years from June 1999 to July 2003. PATIENTS & METHODS: A total of 400 patients undergoing tonsillectomy with or without adenoidectomy were included in this study. These patients were randomly divided into three groups named, A, B and C. One hundred and thirty patients were included in group A, where no antibiotic was given post-operatively. One hundred and thirty five patients each were included in group B and C, where amoxicillin/clavulanic acid was given in group B and cefaclor in group C post-operatively for seven days. Post-operatively all the patients were assessed for pain in the throat, referred otalgia, tune duration for which patient used analgesics, intermittent fever; ford odour from the mouth, post-operative hemorrhage and day of return to a regular diet. RESULTS: This study shows a significant better outcome and reduction in post-operative morbidity in patients where prophylactic antibiotics were used Secondly results were comparable and similar between groups where two different antibiotics were used. CONCLUSION: We recommend routine use of prophylactic antibiotic, which must he broad spectrum and active against beta-lactamase producing organisms.

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