Arshad Naseem, Nuri M M H, Tariq Ahmed.
Genomic medicine in cardiovascular disorders.
Pak Armed Forces Med J Jan ;55(1):56-67.

In this review article, we will give a short analysis of monogenic cardiovascular disorders (illnesses in which consistently single gene has been found to be mutated or defective) which are known to us for long time but are relatively uncommon in our setup. We will than discuss the possible role of genomic medicine in more common polygenic / multifactorial cardiovascular disorders (illnesses caused by several genes acting on a single trait, and possibly gene/environment interaction) like Ischemic Heart Disease, Heart Failure, etc. It will be pertinent to mention that, we will restrict ourselves to only genetic aspects of specific cardiovascular illnesses in the scenario of clinical practice, and clinical features of specific diseases will not be discussed. While major findings in cardiovascular genomics have been few to the date, this review will provide a broad window into how far this field has come and where it is going.

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