Sarah Rahmani Khan, Nisar Ahmed, Nadia Sajid, Saima Farhan, Muneeza Natiq, Abdul Mannan.
Pediatric Myelodysplastic Syndrome (MDS) - case series at the Childrens Hospital & the Institute of Child Health, Lahore.
Pak J Pathol Jan ;15(1):25-7.
A study was planned to determine the pattren of FAB type distribution of myelodysplastric syndrome in childhood haematological malignancies. It was a cross sectional study carried over a twenty-month period in Haematology and Transfusion Medicine Department of Children Hospital and Institute of Child Health. All patients of age suspected of haematological malignancy were included in the study. All patients underwent a complete blood count, reticulocyte count, peripheral blood film from neonate 15 years examination, bone marrow aspiration and trephine biopsy. During a period of 20 months (from Sep 2000 to May 2002) 195 cases of haematological malignancies were diagnosed. Out of these 9 (4.6%) patients were diagnosed as cases of Paediatric MDS. There were 110 cases of acute lymphoplastic leukemia (ALL), 63 cases of acute myeloid leukemia (AML) and 13 cases of chronic myeloid leukemia (CML). Out of the 9 MDS cases five were of MDS Type III - Refractory Anemia with Excess of Blasts-(RAEB) and four were of MDS Type I Refractory Anemia (RA). It can be conducted that paediatric MDS represents 4.6% of all childhood haematological malignancies with nearly equal distribution of REAB and RA.
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