Masoumeh Sadeghi, Hamid Reza Roohafza, Masoud Poormoghadas, Shahin Shirani, Imandokht Golshadi.
Effect of Smoking habit on C-Reactive protein in Iranian population.
Pak J Cardiol Jan ;16(3):138-42.

Objective: Smoking (active or passive) is one of modifiable CVD risk factors. We sought to investigate the effect of environmental tobacco exposure (ETS) on inflammatory marker related to atherosclerosis in Iranian subjects. Methods: We randomly studied on 450 participants, adult in both sexes without clinical evidence of cardiovascular disease. A questionnaire including demographic data, major atherosclerotic risk factors in current, passive and never smoker were filled. Then blood pressure, weight and height were measured. Exposure to passive smoke (>30 minutes per day and >1 day per week) was recorded and occasional and regular smokers were detected. Blood samples were taken for C-reactive protein (CRP). All data entered in SPSS/11 and analyzed by t student, Chi-squared test, Pearson correlation coefficient, and multivariate regression analysis to evaluate the effects of passive smoke on C-reactive protein levels. Results: One hundred fifty (33 %) person in both age were current smoker. In non smokers three same samples (one hundred participants) were in non exposure, occasional and regular exposure groups respectively. Compared with those who were not exposed to passive smoke, those exposed more than 3 days per week had higher levels of C-reactive protein, after adjusting for several potential confounders (p<0.05). Conclusion: We find that CRP was higher in passive smokers. Our findings suggest another pathophysiological mechanism by which exposure to environmental tobacco is associated with the development of atherosclerosis. Therefore we must design intervention study at national level to prohibit smoking in public site and educate people for hazard of passive smoking at home.

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