Birgees Mazhar Kazi, Faiza Kazi, Masood Anwar.
Bone Marrow Fibrosis (BMF): A new proposal for grading system.
Int J Pathol Jan ;1:25-30.

Semi-quantitative evaluation of Bone Marrow Fibrosis (BMF) in trephine biopsies is important in laboratory workup of many haematological lesions. Various grading systems for the study of patterns and extent of Fibrous Tissue Content (FTC) have been used previously. In this paper, a new grading system for FTC has been proposed and studied in trephine biopsies of 160 cases of various haematological lesions. BMF was observed in 59% of cases. The grading system applied in this study was found quite comprehensive, and it was easy to segregate BMF into various grades with the help of this system. Grade 1 fibrosis was the commonest (35.l%), followed by Grade 2 (28.7%), Grade 3 (24.5%) and Grade 4 (11.5%), respectively. Van Giesen`s trichrome stain was found useful for demonstration of collagen in Grade 4 fibrosis.

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