Khalid Hassan, Khalid Hassan, Muhammad Younus, Nadeem Ikram, Lubna Naseem, Hassan Abbas Zaheer.
Red cell alloimmunization in repeatedly transfused Thalassemia Major patients.
Int J Pathol Jan ;2(1):16-9.

Thalassemia major patients managed by regular transfusion regimen may develop anti-red cell alloimmunization. If the alloantibodies are hemolyzing in nature, transfusion reaction may occur, and provision of blood thereafter requires matching of the relevant blood group in addition to `ABO" and Rh `D` matching. We investigated 75 cases of multiply transfused thalassemia major patients for development of alloantibodies against red cells by indirect antiglobulin test, using 3-red cell panel, and when required 11-red cell panel. Anti-red cell alloantibodies were detected in 17 (22.7%) patients. Anti-KV antibodies were the commonest, followed by Anti-e, anti-E and anti-K antibodies, respectively. Anti-k, -Cw, -Fyb, -Kpb, -Rh `D` and —c were detected in one patient each. It is concluded that in multiply transfused patients, alloantibodies develop in a significant number of patients. The hemolyzing nature of antibodies should be determined in patients who develop these antibodies, and transfusion should be arranged accordingly

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