Nabeela Shami, Naghmana Akbar, Shaharyar, Shaila Anwar, Shaheena Asif.
Feasibility of secondary Cytoreductive Surgery for recurrent epithelial ovarian cancer.
J Coll Physicians Surg Pak Jan ;11(7):424-6.

Objective: To determine the feasibility of secondary cytoreductive surgery in patients who present with recurrent epithelial ovarian tumors. Design : Retrospective and prospective. Place and Duration of Study: Gynaecology Unit II of Jinnah Hospital Lahore. Study period extended from July, 1996 to March, 1998. Materials and Methods: A total number of 21 patients, who had undergone initial optimal cytoreductive surgery and combination chemotherapy but had relapsed after a disease-free interval of 6 months or greater, were included. All patients were subjected to secondary cytoreductive surgery. Results: Optimal secondary cytoreduction was possible in 8 (38.09%) patients. 11(52.38%) patients had suboptimal cytoreduction, while 2 (9.52%) were inoperable. The intraoperative morbidity showed injury to the intestine occurred in 3(14.28%) of the patients, severe hemorrhage in 4(19.05%) and visceral perforation in 2(9.52%) patients. There was no operative mortality. Conclusion: Secondary cytoreductive surgery for recurrent epithelial ovarian cancers is a feasible approach but is associated with significant morbidity. Further studies with larger number of patients are needed to clearly define the role of secondary cytoreduction in recurrent epithelial cancer.

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