Abdulrahman Abdulmohsen Alshaikh.
Concomitant use of insulin glargine and NPH in Type-1 Diabetes.
Pak J Med Sci Jan ;22(2):208-10.

In this prospective study on 13 patients with type 1 diabetes we evaluated the glycemic control and hypoglycemic episodes on a combination therapy of NPH and glargine insulin. Glycosylated hemoglobin (HbA1C), fasting (FPG), Post Prandial glucose (PPG), and blood glucose on arrival from the school levels were recorded at baseline and two monthly intervals for 6 months. The mean HbA1C reduced from 9.7 to 7.1%, incidence of hypoglycemia reduced from 1.8 to 1.2, mean Fasting Blood Glucose (FBG) from 121to 108 mg/dl and mean blood glucose on arrival from the school from 287.6 to 167.3 mg/dl over 6 months observation period. This regimen helps us to ovoid hyperglycemia on arrival from the school with no increase in hypoglycemic events.

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