Asma Nazir, M Shafique, Farrukh Kamal, Tasnim A Raza.
Hepatotoxic Effects of Low Dose Endosulfan: A Duration Dependent Histological Study.
Proceeding Shaikh Zayed Postgrad Med Inst Jan ;14(2):77-84.

Endosulfan is a commonly used pesticide and is highly hepatotoxic. This study was designed to assess the histological changes in rat liver produced by a low toxic dose (2.5mg/kg) of endosulfan in a duration dependent manner. Eighty male Albino rats were randomly divided into control group (A) and experimental group (B). Each group was further divided into 4 sub-groups (l, 2, 3 and 4) having 10 animals each. Group B was given daily intraperitoneal injection of 2.5mg/kg endosulfan for 2, 4, 6 and 8 weeks. Control group was injected an equal volume of distilled water for the same duration. At the end of the experiment animals were sacrificed, liver dissected and prepared for histological study under microscope. Endosulfan at a low toxic dose (2.5mg/kg) caused negative growth rate and increased relative tissue weight index (RTWI). Histology revealed dilatation of central veins, sinusoids and portal tract, along with enlargement, cloudy swelling, vacuolation and necrosis of hepatocytes with nuclear changes. All these changes worsened with increase in duration of exposure to endosulfan.

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