Muhammad Rafique Chattha, Kamran Ali, Adnan Aslam, Bilal Afzal, Muhammad Asif Shahzad.
Current concepts in central giant cell granuloma.
Pak Oral Dental J Jan ;26(1):71-8.

Central Giant Cell Granuloma is a nonneoplastic intraosseous lesion, and constitutes a common nonodontogenic pathology to occur in the jaws. It is characterized histologically by cellular fibrous tissue containing multiple foci of haemorrhage, aggregations of multinucleated giant cells, and occasionally, trabeculae of woven bone. Various theories brand it from being a `reactive` to hamartomatous to a neoplastic lesion. It has now been hypothesized that it is the mononuclear spindle shaped cell which controls the proliferative activity of this lesion, as opposed to the more frequently seen giant cell. It has an increased predilection for mandible and females, in younger age groups. Various radiological and histopathological differential diagnoses should be considered in case of giant cell lesions. Some of the lesions are thought to display a markedly `aggressive` behaviour and a clinically `aggressive` model of CGCG has been proposed. Smaller, `nonaggressive` tumours generally respond very well to conservative enucleation or curettage but recurrence is seen to be common with `aggressive` lesions. Various medical therapies including injections of intra lesional steroids, subcutaneous calcitonin and interferon have been proposed for the treatment of `aggressive` lesions. This is a review article.

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